Arsenic as a teratogenic agent.

Arsenic as a teratogenic agent.

Sodium arsenate induces developmental malformations in a variety of experimental animals. In the golden hamster, the intravenous (or intraperitoneal) administration of 20 mg/kg of sodium arsenate during day 8 to 9 of gestation induces a rather specific spectrum of congenital malformations. This period corresponds to the period of very rapid differentiation and major organogenesis in this animal...

Carcinogenic, teratogenic, and mutagenic effects of arsenic.

This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between clinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed. ...

Enzymic differentiation of rat yolk-sac placenta as affected by a teratogenic agent.

A new teratogenic agent applied to amphibian embryos.

It has been demonstrated that the application of the magnetic probe to Drosophila pupae has a pronounced influence on the pattern of morphogenesis (Levengood, 1966). In addition to morphological abnormalities, there was a retardation of development which continued to occur without further treatment in succeeding generations. A theoretical basis for these disturbances has been proposed (Levengoo...

Development of 166Ho-zoledronate as a bone marrow ablative agent

In this study, production, quality control and biodistribution studies of 166Ho-zoledronate have been presented as a possible bone marrow ablative agent. Ho-166 chloride was produced by thermal neutron irradiation of natural 165Ho(NO3)3 samples. 166Ho-zoledronate complex was prepared by adding the desired amount of zoledronate solution (0.2 mL, 150 mg/ml in 1 M NaOH) to appropriate amount of th...